BMS-932481

• Description:

  BMS-932481 is an orally active modulator for γ-secretase, selectively reduce Aβ1-42 and Aβ1-40 production, with IC50s of 6.6 and 25.3 nM, respectively[1].

• UNSPSC:

  12352005

• Target:

  γ-secretase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling; Stem Cell/Wnt

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bms-932481.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CNC1=C(CC[C@H]2C3=CC=C(F)C=C3)C2=NC(NC4=CC=C(N5N=C(C)N=C5)C(OC)=C4)=N1

• Molecular Formula:

  C24H24FN7O

• Molecular Weight:

  445.49

• References & Citations:

  [1]Toyn JH, et al., Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects. J Pharmacol Exp Ther. 2016 Jul;358 (1) :125-37.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1263871-36-8]