KRAS-IN-48

• Description:

  KRAS-IN-48 (Compound 1-01) is a KRAS mutant inhibitor, with Kd values of 2.58 nM and 5.49 μM for KRAS-G12D and KRAS-G12V, respectively. KRAS-IN-48 can be used in the research of cancer[1].

• UNSPSC:

  12352005

• Target:

  Ras

• Related Pathways:

  GPCR/G Protein; MAPK/ERK Pathway

• Field of Research:

  Cancer

• Smiles:

  OC=O.F[C@H](C1)CN(CCC2)[C@]12COC3=NC(N4CC5NC(CC5)C4)=C6N(C7CCC7)C(OC8=CC(O)=CC9=C8C(C#C)=C(F)C=C9)=NC6=N3.OC=O

• Molecular Formula:

  C37H41F2N7O7

• Molecular Weight:

  733.76

• References & Citations:

  [1]Li X, et al. Imidazo Pyrimidine Compounds for the Inhibition of Oncogenic KRAS Mutations in Cancer Therapy. ACS Med Chem Lett. 2025 Oct 30;16 (11) :2194-2196.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  K-Ras

• CAS Number:

  3074833-87-4