HDAC6-IN-48

• UNSPSC Description:

  HDAC6-IN-48 (compound 5i) is a potent and selective HDAC6 inhibitor with IC50 values of 5.16, 396.72, 638.08 nM for HDAC6, HDAC3, HDAC1, respectively. HDAC6-IN-48 induces apoptosis and cell cycle arrest at G0/G1 phase. HDAC6-IN-48 increases the protein expression of acetylated α-tubulin[1].

• Target Antigen:

  Apoptosis; HDAC

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Epigenetics

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hdac6-in-48.html

• Smiles:

  COC1=CC=C(C=C1)C2=CC3=C(NC=C3CC(NC4=CC=C(C=C4)C(NO)=O)=O)C=C2

• Molecular Weight:

  415.44

• References & Citations:

  [1]Li X, et al. Discovery of Potent Selective HDAC6 Inhibitors with 5-Phenyl-1H-indole Fragment: Virtual Screening, Rational Design, and Biological Evaluation. J Chem Inf Model. 2024 Jul 23.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported