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Dapsone-d8

CAT: 0804-HY-B0688S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0688S-01Size:1 mg
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Description
Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].
CAS Number
557794-38-4
Product Name Alternative
4,4′-Diaminodiphenyl sulfone-d8; DDS-d8
UNSPSC
12352005
Hazard Statement
H302
Target
Antibiotic; Bacterial; Parasite; Reactive Oxygen Species (ROS)
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Infection; Inflammation/Immunology
Purity
99.82
Solubility
10 mM in DMSO|DMSO : 250mg/mL (ultrasonic)
Smiles
NC1=C(C([2H])=C(C([2H])=C1[2H])S(C2=C(C([2H])=C(C([2H])=C2[2H])N)[2H])(=O)=O)[2H]
Molecular Formula
C12H4D8N2O2S
Molecular Weight
256.35
Precautions
H302
References & Citations
[1]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[2]Dapsone. Drug.com|[3]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone) .J Infect Dis. 1994 Feb;169 (2) :456-9.|[4]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11 (11) :607.|[5]Wozel G, et al. Dapsone in dermatology and beyond. Arch Dermatol Res. 2014 Mar;306 (2) :103-24. |[6]Noroozi N, et al. Protective Effects of Dapsone on Scopolamine-Induced Memory Impairment in Mice: Involvement of Nitric Oxide Pathway. Dement Geriatr Cogn Dis Extra. 2022 Mar 24;12 (1) :43-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Chemical Information

Benzen-2,3,5,6-d4-amine, 4,4'-sulfonylbis-
CAS Number557794-38-4
PubChem CID11128937
IUPAC Name4-(4-amino-2,3,5,6-tetradeuteriophenyl)sulfonyl-2,3,5,6-tetradeuterioaniline
Molecular FormulaC12H12N2O2S
Molecular Weight256.35
XLogP1
Topological Polar Surface Area94.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count17
Formal Charge0
Complexity306
SMILES
[2H]C1=C(C(=C(C(=C1N)[2H])[2H])S(=O)(=O)C2=C(C(=C(C(=C2[2H])[2H])N)[2H])[2H])[2H]
InChI
InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2/i1D,2D,3D,4D,5D,6D,7D,8D
InChIKey
MQJKPEGWNLWLTK-PGRXLJNUSA-N
Chemical Structure
2D Structure
2D structure of Benzen-2,3,5,6-d4-amine, 4,4'-sulfonylbis-
CAS: 557794-38-4
CID: 11128937
Formula: C12H12N2O2S
MW: 256.35
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight256.35
XLogP31
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass256.11216277
Monoisotopic Mass256.11216277
Topological Polar Surface Area94.6 Ų
Heavy Atom Count17
Formal Charge0
Complexity306
Isotope Atom Count8
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-B0688R-01Dapsone (Standard)
HY-B0688S1Dapsone-d4
HY-G0016-01N-Acetyl dapsone
HY-137155S-01Dapsone hydroxylamine-d4
HY-G0016S-01N-Acetyl dapsone-d4
HY-G0016S1-01N-Acetyl dapsone-d4-1

Alternative Products

CatalogName
CS-O-06528Dapsone-d8
TRC-D193255-10MGDapsone-D8 (major)
AR-D01202-01Monoacetyl Dapsone-d8
CS-O-44665Dapsone-d8 DiHydrochloride
CS-O-11239N-Acetyl Dapsone-d8
TRC-A168437-1MGN-Acetyl Dapsone-d8 (Major)
B3448-1000Dapsone

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