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Dapsone hydroxylamine

CAT: 0804-HY-137155-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137155-01Size:5 mg
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Description
Dapsone hydroxylamine (DDS-NOH) induces methemoglobinemia. Dapsone hydroxylamine inhibits catalase (CAT) activity and reactive oxygen species generation. Dapsone hydroxylamine also has anti-inflammatory activity[1].
CAS Number
32695-27-5
Product Name Alternative
DDS-NOH
UNSPSC
12352005
Hazard Statement
H302+H312
Target
Drug Metabolite; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dapsone-hydroxylamine.html
Purity
94.92
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(C=C1)N)(C2=CC=C(C=C2)NO)=O
Molecular Formula
C12H12N2O3S
Molecular Weight
264.30
Precautions
H302+H312
References & Citations
[1]Albuquerque RV, et al. In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells. PLoS One. 2015 Aug 18;10 (8) :e0134768.|[2]Wozel G, et al. Dapsone hydroxylamine inhibits the LTB4-induced chemotaxis of polymorphonuclear leukocytes into human skin: results of a pilot study. Inflamm Res. 1997 Oct;46 (10) :420-2.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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