Dapsone hydroxylamine

• Description:

  Dapsone hydroxylamine (DDS-NOH) induces methemoglobinemia. Dapsone hydroxylamine inhibits catalase (CAT) activity and reactive oxygen species generation. Dapsone hydroxylamine also has anti-inflammatory activity[1].

• Product Name Alternative:

  DDS-NOH

• UNSPSC:

  12352005

• Hazard Statement:

  H302+H312

• Target:

  Drug Metabolite; Reactive Oxygen Species (ROS)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/dapsone-hydroxylamine.html

• Purity:

  94.92

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S (C1=CC=C (C=C1) N) (C2=CC=C (C=C2) NO) =O

• Molecular Formula:

  C12H12N2O3S

• Molecular Weight:

  264.30

• Precautions:

  H302+H312

• References & Citations:

  [1]Albuquerque RV, et al. In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells. PLoS One. 2015 Aug 18;10 (8) :e0134768.|[2]Wozel G, et al. Dapsone hydroxylamine inhibits the LTB4-induced chemotaxis of polymorphonuclear leukocytes into human skin: results of a pilot study. Inflamm Res. 1997 Oct;46 (10) :420-2.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  32695-27-5