Dapsone hydroxylamine

• Description :

  Dapsone hydroxylamine (DDS-NOH) induces methemoglobinemia. Dapsone hydroxylamine inhibits catalase (CAT) activity and reactive oxygen species generation. Dapsone hydroxylamine also has anti-inflammatory activity[1].

• Product Name Alternative :

  DDS-NOH

• UNSPSC :

  12352005

• Hazard Statement :

  H302+H312

• Target :

  Drug Metabolite; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/dapsone-hydroxylamine.html

• Purity :

  94.92

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(C1=CC=C(C=C1)N)(C2=CC=C(C=C2)NO)=O

• Molecular Formula :

  C12H12N2O3S

• Molecular Weight :

  264.30

• Precautions :

  H302+H312

• References & Citations :

  [1]Albuquerque RV, et al. In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells. PLoS One. 2015 Aug 18;10 (8) :e0134768.|[2]Wozel G, et al. Dapsone hydroxylamine inhibits the LTB4-induced chemotaxis of polymorphonuclear leukocytes into human skin: results of a pilot study. Inflamm Res. 1997 Oct;46 (10) :420-2.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [32695-27-5]