Dapsone (Standard)

• UNSPSC Description:

  Dapsone (Standard) is the analytical standard of Dapsone. This product is intended for research and analytical applications. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].

• Target Antigen:

  Antibiotic; Bacterial; Parasite; Reactive Oxygen Species

• Type:

  Reference Standards

• Related Pathways:

  Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/dapsone-standard.html

• Purity:

  99.77

• Smiles:

  O=S(C1=CC=C(N)C=C1)(C2=CC=C(N)C=C2)=O

• Molecular Weight:

  248.30

• References & Citations:

  [1]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[2]Dapsone, Drug.com|[3]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;169(2):456-9.|[4]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11(11):607.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• CAS Number:

  80-08-0