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Dapsone (Standard)

CAT: 0804-HY-B0688R-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0688R-01Size:50 mg
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Description
Dapsone (Standard) is the analytical standard of Dapsone. This product is intended for research and analytical applications. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].
CAS Number
[80-08-0]
Product Name Alternative
4,4′-Diaminodiphenyl sulfone (Standard) ; DDS (Standard)
UNSPSC
12352005
Hazard Statement
H302, H360, H371, H373, H411
Target
Antibiotic; Bacterial; Parasite; Reactive Oxygen Species (ROS) ; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dapsone-standard.html
Purity
99.77
Smiles
O=S(C1=CC=C(N)C=C1)(C2=CC=C(N)C=C2)=O
Molecular Formula
C12H12N2O2S
Molecular Weight
248.30
Precautions
H302, H360, H371, H373, H411
References & Citations
[1]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[2]Dapsone, Drug.com|[3]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone) .J Infect Dis. 1994 Feb;169 (2) :456-9.|[4]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11 (11) :607.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

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