Dapsone (Standard)

• Description:

  Dapsone (Standard) is the analytical standard of Dapsone. This product is intended for research and analytical applications. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].

• Product Name Alternative:

  4,4′-Diaminodiphenyl sulfone (Standard) ; DDS (Standard)

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H360, H371, H373, H411

• Target:

  Antibiotic; Bacterial; Parasite; Reactive Oxygen Species (ROS) ; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/dapsone-standard.html

• Purity:

  99.77

• Smiles:

  O=S(C1=CC=C(N)C=C1)(C2=CC=C(N)C=C2)=O

• Molecular Formula:

  C12H12N2O2S

• Molecular Weight:

  248.30

• Precautions:

  H302, H360, H371, H373, H411

• References & Citations:

  [1]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[2]Dapsone, Drug.com|[3]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone) .J Infect Dis. 1994 Feb;169 (2) :456-9.|[4]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11 (11) :607.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C, sealed storage, away from light and moisture

• Scientific Category:

  Reference Standards

• CAS Number:

  [80-08-0]