Dapsone-d8

Dapsone-d8

• CAS Number: 557794-38-4
• UNSPSC Description: Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].
• Target Antigen: Antibiotic; Bacterial; Parasite; Reactive Oxygen Species
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Cancer; Infection; Inflammation/Immunology
• Purity: 99.82
• Solubility: 10 mM in DMSO
• Smiles: NC1=C(C([2H])=C(C([2H])=C1[2H])S(C2=C(C([2H])=C(C([2H])=C2[2H])N)[2H])(=O)=O)[2H]
• Molecular Weight: 256.35
• References & Citations: [1]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[2]Dapsone. Drug.com|[3]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).J Infect Dis. 1994 Feb;169(2):456-9.|[4]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11(11):607.|[5]Wozel G, et al. Dapsone in dermatology and beyond. Arch Dermatol Res. 2014 Mar;306(2):103-24. |[6]Noroozi N, et al. Protective Effects of Dapsone on Scopolamine-Induced Memory Impairment in Mice: Involvement of Nitric Oxide Pathway. Dement Geriatr Cogn Dis Extra. 2022 Mar 24;12(1):43-50.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported