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Dapsone-d8

CAT: 0804-HY-B0688S-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0688S-01Size:1 mg
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Description
Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].
CAS Number
[557794-38-4]
Product Name Alternative
4,4′-Diaminodiphenyl sulfone-d8; DDS-d8
UNSPSC
12352005
Hazard Statement
H302
Target
Antibiotic; Bacterial; Parasite; Reactive Oxygen Species (ROS)
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Infection; Inflammation/Immunology
Purity
99.82
Solubility
10 mM in DMSO|DMSO : 250mg/mL (ultrasonic)
Smiles
NC1=C(C([2H])=C(C([2H])=C1[2H])S(C2=C(C([2H])=C(C([2H])=C2[2H])N)[2H])(=O)=O)[2H]
Molecular Formula
C12H4D8N2O2S
Molecular Weight
256.35
Precautions
H302
References & Citations
[1]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[2]Dapsone. Drug.com|[3]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone) .J Infect Dis. 1994 Feb;169 (2) :456-9.|[4]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11 (11) :607.|[5]Wozel G, et al. Dapsone in dermatology and beyond. Arch Dermatol Res. 2014 Mar;306 (2) :103-24. |[6]Noroozi N, et al. Protective Effects of Dapsone on Scopolamine-Induced Memory Impairment in Mice: Involvement of Nitric Oxide Pathway. Dement Geriatr Cogn Dis Extra. 2022 Mar 24;12 (1) :43-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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