Dapsone-d8

• Description:

  Dapsone-d8 is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities[1]. Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases[2][3][4][5].

• Product Name Alternative:

  4,4′-Diaminodiphenyl sulfone-d8; DDS-d8

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Antibiotic; Bacterial; Parasite; Reactive Oxygen Species (ROS)

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Purity:

  99.82

• Solubility:

  10 mM in DMSO|DMSO : 250mg/mL (ultrasonic)

• Smiles:

  NC1=C(C([2H])=C(C([2H])=C1[2H])S(C2=C(C([2H])=C(C([2H])=C2[2H])N)[2H])(=O)=O)[2H]

• Molecular Formula:

  C12H4D8N2O2S

• Molecular Weight:

  256.35

• Precautions:

  H302

• References & Citations:

  [1]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[2]Dapsone. Drug.com|[3]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone) .J Infect Dis. 1994 Feb;169 (2) :456-9.|[4]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11 (11) :607.|[5]Wozel G, et al. Dapsone in dermatology and beyond. Arch Dermatol Res. 2014 Mar;306 (2) :103-24. |[6]Noroozi N, et al. Protective Effects of Dapsone on Scopolamine-Induced Memory Impairment in Mice: Involvement of Nitric Oxide Pathway. Dement Geriatr Cogn Dis Extra. 2022 Mar 24;12 (1) :43-50.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [557794-38-4]