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Dapsone-d4

CAT: 0804-HY-B0688S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0688S1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dapsone-d4 is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].
CAS Number
1346602-12-7
Product Name Alternative
4,4′-Diaminodiphenyl sulfone-d4; DDS-d4
UNSPSC
12352005
Target
Antibiotic; Bacterial; Isotope-Labeled Compounds; Parasite; Reactive Oxygen Species (ROS)
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Infection; Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
O=S(C1=C([2H])C([2H])=C(C([2H])=C1[2H])N)(C2=CC=C(C=C2)N)=O
Molecular Formula
C12H8D4N2O2S
Molecular Weight
252.33
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[3]Dapsone, Drug.com|[4]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone) .J Infect Dis. 1994 Feb;169 (2) :456-9.|[5]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11 (11) :607.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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