N-Acetyl dapsone

• Description:

  N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688) . Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1][2].

• Product Name Alternative:

  MADDS; Monoacetyldapsone

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Drug Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/n-acetyl-dapsone.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC (NC1=CC=C (S (=O) (C2=CC=C (N) C=C2) =O) C=C1) =O

• Molecular Formula:

  C14H14N2O3S

• Molecular Weight:

  290.34

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Tanaka K, et al. Mutagenicity of N-acetyl and N, N'-diacetyl derivatives of 3 aromatic amines used as epoxy-resin hardeners. Mutat Res. 1985 May-Jun;143 (1-2) :11-5.|[2]Bonde S L, et al. Simultaneous determination of dapsone and its major metabolite N-Acetyl Dapsone by LC-MS/MS method. Int. J. Pharm. Pharm. Sci, 2013, 5: 441-446.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  565-20-8