N-Acetyl dapsone

• Description :

  N-Acetyl dapsone (MADDS) is the major metabolite of Dapsone (HY-B0688) . Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1][2].

• CAS Number :

  [565-20-8]

• Product Name Alternative :

  MADDS; Monoacetyldapsone

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Drug Metabolite

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/n-acetyl-dapsone.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(NC1=CC=C(S(=O)(C2=CC=C(N)C=C2)=O)C=C1)=O

• Molecular Formula :

  C14H14N2O3S

• Molecular Weight :

  290.34

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Tanaka K, et al. Mutagenicity of N-acetyl and N, N'-diacetyl derivatives of 3 aromatic amines used as epoxy-resin hardeners. Mutat Res. 1985 May-Jun;143 (1-2) :11-5.|[2]Bonde S L, et al. Simultaneous determination of dapsone and its major metabolite N-Acetyl Dapsone by LC-MS/MS method. Int. J. Pharm. Pharm. Sci, 2013, 5: 441-446.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported