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Dapsone-13C12

CAT: 0804-HY-B0688S2-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0688S2-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dapsone-13C12 is the 13C12 labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[1][2][3][4][5].
CAS Number
1632119-29-9
Product Name Alternative
4,4′-Diaminodiphenyl sulfone-13C12; DDS-13C12
UNSPSC
12352005
Hazard Statement
H302
Target
Antibiotic; Bacterial; Isotope-Labeled Compounds; Parasite; Reactive Oxygen Species (ROS)
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dapsone-13c12.html
Solubility
10 mM in DMSO
Smiles
O=S([13C]1=[13CH][13CH]=[13C]([13CH]=[13CH]1)N)([13C]2=[13CH][13CH]=[13C]([13CH]=[13CH]2)N)=O
Molecular Formula
13C12H12N2O2S
Molecular Weight
260.21
Precautions
P264-P270-P330-P501
References & Citations
[1]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone) .J Infect Dis. 1994 Feb;169 (2) :456-9.|[2]Dapsone, Drug.com|[3]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11 (11) :607.|[4]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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