E-4031 (free base)

• Description :

  E-4031 free base is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies[1].

• CAS Number :

  [113558-89-7]

• UNSPSC :

  12352005

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/e-4031-free-base.html

• Smiles :

  CS(=O)(NC1=CC=C(C(C2CCN(CCC3=NC(C)=CC=C3)CC2)=O)C=C1)=O

• Molecular Formula :

  C21H27N3O3S

• Molecular Weight :

  401.52

• References & Citations :

  [1]Daisuke Izumi, et al. Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog. Pacing Clin Electrophysiol. 2010 Aug;33 (8) :950-9.|[2]E E Verheijck, et al. Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit. Circ Res. 1995 Apr;76 (4) :607-15.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported