E-4031

• Description :

  E-4031 is a selective hERG potassium channel blocker for use in class III anti-arrhythmic studies[1].

• CAS Number :

  [113559-13-0]

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/E-4031.html

• Purity :

  99.40

• Solubility :

  H2O : ≥ 50 mg/mL

• Smiles :

  CS(=O)(NC1=CC=C(C(C2CCN(CCC3=NC(C)=CC=C3)CC2)=O)C=C1)=O.[H]Cl.[H]Cl

• Molecular Formula :

  C21H29Cl2N3O3S

• Molecular Weight :

  474.44

• Precautions :

  H302

• References & Citations :

  [1]Daisuke Izumi, et al. Effects of bepridil versus E-4031 on transmural ventricular repolarization and inducibility of ventricular tachyarrhythmias in the dog. Pacing Clin Electrophysiol. 2010 Aug;33 (8) :950-9.|[2] E E Verheijck, et al. Effects of delayed rectifier current blockade by E-4031 on impulse generation in single sinoatrial nodal myocytes of the rabbit. Circ Res. 1995 Apr;76 (4) :607-15.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2