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E-2508 (free base)

CAT: 0804-HY-119114Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-119114Size:1 Each
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Description
E-2508 free base is an orally active and highly selective corticotropin-releasing factor type 1 receptor (CRF1) antagonist with anxiolytic effects (Ki=11 nM) . E-2508 free base blocks CRF-induced cAMP accumulation via CRF1 receptor inhibition. E-2508 free base is promising for research of stress-related psychiatric disorders, such as anxiety and depression[1].
CAS Number
685885-75-0
UNSPSC
12352005
Target
CRFR
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
CCC1=NN2C(C3=C(C=C(C=C3OC)COC)OC)=CC=CC2=C1N(CC4CCOCC4)CC5CC5
Molecular Formula
C29H39N3O4
Molecular Weight
493.64
References & Citations
[1]Takahashi Y, et al. Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem. 2012 Jun 14;55 (11) :5255-69.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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