TC-S 7005

CAT: 0804-HY-108597-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-108597-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively[1].

CAS Number

1082739-92-1

UNSPSC

12352005

Target

Polo-like Kinase (PLK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tc-s-7005.html

Purity

99.68

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

C[C@H](NC1=CC2=C(ON=C2C3=CC=C(OCO4)C4=C3)C=N1)C5=CC=CC=C5

Molecular Formula

C21H17N3O3

Molecular Weight

359.38

References & Citations

[1]Hanan EJ, et al. Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors. Bioorg Med Chem Lett. 2008 Oct 1;18 (19) :5186-9.|[2]Stephan Reinhard Künzel, et al. Hypoxia-induced epigenetic silencing of polo-like kinase 2 promotes fibrosis in atrial fibrillation. bioRxiv 445098

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PLK1; PLK2; PLK3

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Alternative Products

Catalog	Name
B5604-10	TC-S 7005
A19952-1	TC-S 7005 1mg
A19952-10	TC-S 7005 10mg
A19952-25	TC-S 7005 25mg
A19952-100	TC-S 7005 100mg
A19952-5	TC-S 7005 5mg
A19952-2	TC-S 7005 2mg
A19952-50	TC-S 7005 50mg
A19952-10mM-D	TC-S 7005 10mM * 1mL in DMSO
T17009-01	TC-S 7009

TC-S 7005

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