TC-S 7009

CAT: 0804-HY-18371-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-18371-01Size:5 mg

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Description

TC-S 7009 is a potent and selective HIF-2α inhibitor with a Kd of 81 nM. TC-S 7009 is more selective for HIF-2α than HIF-1α (Kd 5 μM) . TC-S 7009 disrupts HIF-2α heterodimerization, decreases DNA-binding activity, and reduces HIF-2α target gene expression[1][2].

CAS Number

1422955-31-4

UNSPSC

12352005

Hazard Statement

H301, H413

Target

HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tc-s-7009.html

Concentration

10mM

Purity

99.81

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

ClC1=CC(NC2=C([N+]([O-])=O)C3=NON=C3C=C2)=CC(F)=C1

Molecular Formula

C12H6ClFN4O3

Molecular Weight

308.65

Precautions

H301, H413

References & Citations

[1]Scheuermann TH, et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 2013 Apr;9 (4) :271-6.|[2]Senavirathna LK, et al. Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling. Sci Rep. 2018 Feb 9;8 (1) :2709.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

N-(3-Chloro-5-Fluorophenyl)-4-Nitro-2,1,3-Benzoxadiazol-5-Amine

CAS Number	1422955-31-4
PubChem CID	70697712
IUPAC Name	N-(3-chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
Molecular Formula	C12H6ClFN4O3
Molecular Weight	308.65
XLogP	3.8
Topological Polar Surface Area	96.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Heavy Atom Count	21
Formal Charge	0
Complexity	399

SMILES

C1=CC2=NON=C2C(=C1NC3=CC(=CC(=C3)Cl)F)[N+](=O)[O-]

InChI

InChI=1S/C12H6ClFN4O3/c13-6-3-7(14)5-8(4-6)15-10-2-1-9-11(17-21-16-9)12(10)18(19)20/h1-5,15H

InChIKey

CDQUJZKBRAFWNG-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1422955-31-4

CID: 70697712

Formula: C12H6ClFN4O3

MW: 308.65

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	308.65
XLogP3	3.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	2
Exact Mass	308.0112459
Monoisotopic Mass	308.0112459
Topological Polar Surface Area	96.8 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	399
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
T17009-01	TC-S 7009
256857	TC-S 7005
256855	TC-S 7003
B1203-25	TC-S 7010
bs-6861C-01	TC-S 7001
562293	TC-S 7006
TRC-T012670-250MG	TC-S 7004

TC-S 7009

Chemical Information

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