(S)-FTY720-phosphonate

(S)-FTY720-phosphonate

• CAS Number: 1142015-10-8
• UNSPSC Description: FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.
• Target Antigen: LPL Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/s-fty720-phosphonate.html
• Solubility: DMSO : 25 mg/mL (ultrasonic;adjust pH to 2 with 1M HCl)
• Smiles: O=P(O)(O)CC[C@@](CO)(N)CCC1=CC=C(C=C1)CCCCCCCC
• Molecular Weight: 385.48
• References & Citations: [1]Wang L, et al. FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury. Crit Care Med. 2014 Mar;42(3):e189-99.|[2]Lingling Jia, et al. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported