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(R) -FTY720-vinylphosphonate

CAT: 0804-HY-112485Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-112485Size:1 Each
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Description
(R) -FTY720-vinylphosphonate is a sphingosine kinase 1 (SK1) inhibitor. (R) -FTY720-ene-phosphonate is also an FTY720 analogue. (R) -FTY720-vinylphosphonate is promising for research of solid tumors like breast cancer[1].
CAS Number
1142015-25-5
UNSPSC
12352005
Target
Drug Derivative; SphK
Related Pathways
Immunology/Inflammation; Others
Field of Research
Cancer
Smiles
O=P(O)(O)/C=C/[C@](CO)(N)CCC1=CC=C(C=C1)CCCCCCCC
Molecular Formula
C20H34NO4P
Molecular Weight
383.46
References & Citations
[1]Lim KG, et al. FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells. J Biol Chem. 2011 May 27;286 (21) :18633-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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