FTY720 (S) -Phosphate

• Description :

  FTY720 (S) -Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

• Product Name Alternative :

  (S) -FTY720P; (S) -FTY720 phosphate

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335, H336

• Target :

  LPL Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/FTY720__S_-Phosphate.html

• Purity :

  99.57

• Solubility :

  DMSO : 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : < 0.1 mg/mL

• Smiles :

  OC[C@](CCC1=CC=C(CCCCCCCC)C=C1)(N)COP(O)(O)=O

• Molecular Formula :

  C19H34NO5P

• Molecular Weight :

  387.45

• Precautions :

  H302, H315, H319, H335, H336

• References & Citations :

  [1]Wang L, et al. FTY720 (s) -phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury. Crit Care Med. 2014 Mar;42 (3) :e189-99.|[2]Lingling Jia, et al. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [402616-26-6]