DORA 42

• UNSPSC Description:

  DORA 42 is a dual orexin 1 and orexin 2 receptor antagonist with sleep efficacy in rats. DORA 42 is promising for research of insomnia[1].

• Target Antigen:

  Orexin Receptor (OX Receptor)

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/dora-42.html

• Smiles:

  NC1=C2C(SC=C2C)=NC(N3CCN([C@@H](CC3)C)C(C4=C(N5N=CC=N5)C=CC=C4)=O)=N1

• Molecular Weight:

  448.54

• References & Citations:

  [1]Roecker AJ, et al. Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis. Bioorg Med Chem Lett. 2014 May 1;24(9):2079-85.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1030377-48-0