DORA 42

• Description :

  DORA 42 is a dual orexin 1 and orexin 2 receptor antagonist with sleep efficacy in rats. DORA 42 is promising for research of insomnia[1].

• UNSPSC :

  12352005

• Target :

  Orexin Receptor (OX Receptor)

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/dora-42.html

• Smiles :

  NC1=C2C(SC=C2C)=NC(N3CCN([C@@H](CC3)C)C(C4=C(N5N=CC=N5)C=CC=C4)=O)=N1

• Molecular Formula :

  C22H24N8OS

• Molecular Weight :

  448.54

• References & Citations :

  [1]Roecker AJ, et al. Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis. Bioorg Med Chem Lett. 2014 May 1;24 (9) :2079-85.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1030377-48-0]