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SHP2-IN-42

CAT: 0804-HY-175520Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175520Size:1 Each
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Description
SHP2-IN-42 is a src homology 2 domain-containing phosphatase 2 (SHP2) inhibitor with an IC50 of 15 nM. SHP2-IN-42 inhibits cell proliferation and induces apoptosis and G1 phase cell cycle arrest. SHP2-IN-42 can be used for the research of cancer, such as acute myeloid leukemia (AML) [1].
UNSPSC
12352005
Target
Apoptosis; Phosphatase; SHP2
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
C[C@@H]1OCC2([C@@H]1N)CCN(CC2)C3=NN4C=CC(C5=CC=C(C=C5)N6C=CC=C6C(O)=O)=C4C(N3C)=O
Molecular Formula
C27H30N6O4
Molecular Weight
502.56
References & Citations
[1]Zhang M, et al. Structure-guided expansion strategy unveils potent allosteric SHP2 inhibitors with synergistic efficacy against AML through MCL-1 co-targeting. Eur J Med Chem. 2025 Nov 15;298:117988.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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