SH-42

• Description:

  SH-42 is a potent and selective inhibitor of human Δ24-dehydrocholesterol reductase (DHCR24), with an IC50 of 42 nM. SH-42 can lead to a significant increase in plasma desmosterol levels of mice[1].

• UNSPSC:

  12352211

• Target:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/sh-42.html

• Purity:

  99.87

• Solubility:

  DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  C[C@@]12[C@]3([H])C([C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)COC=O)C)=CC[C@@]1([H])C[C@H](CC2)OC(C)=O

• Molecular Formula:

  C25H38O4

• Molecular Weight:

  402.57

• References & Citations:

  [1]Müller C, et, al. New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductase. Eur J Med Chem. 2017 Nov 10;140:305-320.|[2]Desirée Heerdegen, et al. Synthesis of Seco-Analogues of the DHCR24 Inhibitor SH-42. Chemistry europe. 05 September 2020

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2143952-36-5]