AC-42

• Description :

  AC-42 is a poent M1 muscarinic selective allosteric agonist with EC50s of 805 nM and 220 nM for human wild-type and Y381A mutated M1 receptors, respectively. AC-42 stimulates the IP-accumulation and calcium mobilization in CHO cells[1][2].

• UNSPSC :

  12352005

• Target :

  MAChR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ac-42.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(CCCN1CCC(CC1)CCCC)C2=CC=CC=C2C

• Molecular Formula :

  C20H31NO

• Molecular Weight :

  301.47

• References & Citations :

  [1]Marlene A Jacobson, et al. The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'- (2-methylbenzyl) -1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site. Mol Pharmacol. 2010 Oct;78 (4) :648-57.|[2]Langmead CJ, et al., Probing the molecular mechanism of interaction between 4-n-butyl-1-[4- (2-methylphenyl) -4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M (1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist. Mol Pharmacol. 2006 Jan;69 (1) :236-46.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [244291-63-2]