Products for Research Use Only
RegisterLogin

DORA-22

CAT: 0804-HY-101260-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-101260-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
DORA-22 is an orally active dual orexinergic receptor antagonist, and improves the sleep disruption and memory impairment. DORA-22 can be used for study of insomnia[1][2].
CAS Number
1088991-95-0
UNSPSC
12352005
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dora-22.html
Purity
97.67
Smiles
FC1=CC(C(N2C[C@H](COC3=NC=C(F)C=C3)CC[C@H]2C)=O)=C(C4=NC=CC=N4)C=C1
Molecular Formula
C23H22F2N4O2
Molecular Weight
424.44
References & Citations
[1]Gamble MC, et al. The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model. Sleep. 2020;43 (3) :zsz241. |[2]Lin Y, Ret al. Positive allosteric adenosine A2A receptor modulation suppresses insomnia associated with mania- and schizophrenia-like behaviors in mice. Front Pharmacol. 2023;14:1138666. Published 2023 Apr 19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-113555DORA 42
HY-W459528-0122-Methoxy-22-oxodocosanoic acid
HY-W046348-0122- (tert-Butoxy) -22-oxodocosanoic acid
HY-175869Ferroptosis-IN-22
HY-168212PDE4-IN-22
HY-157384BChE-IN-22
HY-157516-01CDK2-IN-22
HY-161983Neuraminidase-IN-22
HY-149031DHODH-IN-22
HY-153950CDK7-IN-22

Alternative Products

CatalogName
T5500-01DORA-22
GTR19200344-01DORA 42
MBS642072-01IGSF6 (DORA, Immunoglobulin Superfamily Member 6, Protein DORA)
GTR18887047-01Human DORA protein
MBS7609031-01Recombinant Human DORA
128359-PEIGSF6 (DORA, Immunoglobulin Superfamily Member 6, Protein DORA) (PE)
128359-BiotinIGSF6 (DORA, Immunoglobulin Superfamily Member 6, Protein DORA) (Biotin)
128359-APCIGSF6 (DORA, Immunoglobulin Superfamily Member 6, Protein DORA) (APC)
128358-HRPIGSF6 (DORA, Immunoglobulin Superfamily Member 6, Protein DORA) (HRP)
128359-FITCIGSF6 (DORA, Immunoglobulin Superfamily Member 6, Protein DORA) (FITC)

Popular Products