BMS-741672

• Description:

  BMS-741672 is a selective and orally active CCR2 antagonist with an IC50 of 1.1 nM. BMS-741672 shows >700-fold selective for CCR2 than CCR5[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  CCR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/bms-741672.html

• Smiles:

  CC (N[C@H]1[C@@H] (N2C ([C@H] (CC2) NC3=NC=NC4=C3C=C (C (F) (F) F) C=C4) =O) CC[C@H] (C1) N (C) C (C) C) =O

• Molecular Formula:

  C25H33F3N6O2

• Molecular Weight:

  506.56

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Michael G Yang, et al. Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672. ACS Med Chem Lett. 2019 Jan 16;10 (3) :300-305.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  CCR2; CCR5

• CAS Number:

  1004757-96-3