BMS-741672

CAT: 0804-HY-108432Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-108432Size:1 Each
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Description
BMS-741672 is a selective and orally active CCR2 antagonist with an IC50 of 1.1 nM. BMS-741672 shows >700-fold selective for CCR2 than CCR5[1].
CAS Number
[1004757-96-3]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bms-741672.html
Smiles
CC(N[C@H]1[C@@H](N2C([C@H](CC2)NC3=NC=NC4=C3C=C(C(F)(F)F)C=C4)=O)CC[C@H](C1)N(C)C(C)C)=O
Molecular Formula
C25H33F3N6O2
Molecular Weight
506.56
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Michael G Yang, et al. Use of a Conformational-Switching Mechanism to Modulate Exposed Polarity: Discovery of CCR2 Antagonist BMS-741672. ACS Med Chem Lett. 2019 Jan 16;10 (3) :300-305.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CCR2; CCR5

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