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PROTAC SMARCA2 degrader-16

CAT: 0931-T200618-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T200618-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2568276-37-7
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC targeting SMARCA2. It demonstrates degradation of the SMARCA2 protein with a DC50<100 nM in A549 cells, achieving a maximal degradation rate (Dmax%) of over 90% after 24 hours of treatment.
Smiles
O=C1NC(=O)C(N2C(=O)N(C3=CC(=CC=C32)CCCN4CCC(C5=NC=CC(=N5)N6C7CN(C=8C=C(N=NC8N)C9=CC=CC=C9O)CC6CC7)CC4)C)CC1
Molecular Formula
C41H47N11O4
Molecular Weight
757.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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