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Compound 48/80

CAT: 0804-HY-115768-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-115768-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways[1][2].
CAS Number
94724-12-6
Product Name Alternative
Poly-p-methoxyphenethylmethylamine
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/compound-48-80.html
Purity
99.98
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CNCCC1=CC(CC2=CC(CCNC)=CC=C2OC)=C(OC)C(CC3=CC(CCNC)=CC=C3OC)=C1
Molecular Formula
C32H45N3O3
Molecular Weight
519.72
References & Citations
[1]Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7 (12) :e52104. |[2]Wang YH, Taché Y, Harris AG, Kreutner W, Daly AF, Wei JY. Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique. Allergy. 2005;60 (1) :117-124. |[3]Darzynkiewicz Z, Carter S. Compound 48/80 impairs cytokinesis in murine leukemic cells. J Cell Physiol. 1984;119 (1) :1-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Int Immunopharmacol. 2025 May 19:159:114880.|J Invest Dermatol. 2025 Nov 4:S0022-202X (25) 03517-1.|SSRN. 2025 Nov 25.

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