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CXF-009

CAT: 0804-HY-160621Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-160621Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CXF-009 is a selective and covalent FGFR4 inhibitor, with the IC50 of 48 nM. CXF-009 targeting Cys477 and Cys552 of FGFR4, and can be used for the study of hepatocellular carcinoma[1].
CAS Number
[2727084-00-4]
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cxf-009.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(NC2=NC=C3C(N(CCCN4CCN(CC4)C(C=C)=O)C(N(C3)C5=CC(OC)=CC(OC)=C5)=O)=N2)C=CC=C1)C=C
Molecular Formula
C33H38N8O5
Molecular Weight
626.71
References & Citations
[1]Chen X, et al. Structure-based design of a dual-warhead covalent inhibitor of FGFR4. Commun Chem. 2022;5 (1) :36. Published 2022 Mar 17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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