AGS-009

• Description :

  AGS-009 is a humanized monoclonal neutralising antibody targeting IFN-α. AGS-009 significantly reduces activated lymphocytes, such as CD4+ and CD8+ T cells as well as B cells in SIV infection rhesus macaque models. AGS-009 can be used for autoimmune diseases like systemic lupus erythematosus (SLE) and HIV infections research[1][2].

• UNSPSC :

  12352100

• Target :

  HIV; IFNAR

• Related Pathways :

  Anti-infection; Immunology/Inflammation

• Field of Research :

  Infection; Inflammation/Immunology

• References & Citations :

  [1]Mathian A, et al. Targeting interferons in systemic lupus erythematosus: current and future prospects. Drugs. 2015 May;75 (8) :835-46.|[2]Carnathan D, et al. Reduced Chronic Lymphocyte Activation following Interferon Alpha Blockade during the Acute Phase of Simian Immunodeficiency Virus Infection in Rhesus Macaques. J Virol. 2018 Apr 13;92 (9) :e01760-17.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Inhibitory Antibodies

• Clinical Information :

  No Development Reported