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BChE-IN-36

CAT: 0804-HY-169163Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169163Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BChE-IN-36 (compound 40) is a potent hCA activator and BChE inhibitor with KA values of 266, 76.9, 918, 893, 98.0 nM for hCA I, hCA II, hCA IV, hCA VB, hCA VII, IC50 values of 72.1, 4.2 nM for eeAChE, eqBChE, respectively. BChE-IN-36 shows no cytotoxicity. BChE-IN-36 shows potent procognitive effects. BChE-IN-36 has the potential for the research of neurodegenerative diseases and other neuropsychiatric disorders[1].
UNSPSC
12352005
Target
Carbonic Anhydrase; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hbche-in-4.html
Smiles
O=C([C@@H](NCCCCCCNC1=C2CCCCC2=NC3=CC=CC=C31)CC4=CNC=N4)OC
Molecular Formula
C26H35N5O2
Molecular Weight
449.59
References & Citations
[1]Nocentini A, et al. Enhanced Recognition Memory through Dual Modulation of Brain Carbonic Anhydrases and Cholinesterases. J Med Chem. 2024 Sep 26;67 (18) :16873-16898.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; CA; CA II; CA I

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