BChE-IN-36

• Description:

  BChE-IN-36 (compound 40) is a potent hCA activator and BChE inhibitor with KA values of 266, 76.9, 918, 893, 98.0 nM for hCA I, hCA II, hCA IV, hCA VB, hCA VII, IC50 values of 72.1, 4.2 nM for eeAChE, eqBChE, respectively. BChE-IN-36 shows no cytotoxicity. BChE-IN-36 shows potent procognitive effects. BChE-IN-36 has the potential for the research of neurodegenerative diseases and other neuropsychiatric disorders[1].

• UNSPSC:

  12352005

• Target:

  Carbonic Anhydrase; Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/hbche-in-4.html

• Smiles:

  O=C([C@@H](NCCCCCCNC1=C2CCCCC2=NC3=CC=CC=C31)CC4=CNC=N4)OC

• Molecular Formula:

  C26H35N5O2

• Molecular Weight:

  449.59

• References & Citations:

  [1]Nocentini A, et al. Enhanced Recognition Memory through Dual Modulation of Brain Carbonic Anhydrases and Cholinesterases. J Med Chem. 2024 Sep 26;67 (18) :16873-16898.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE; BChE; CA; CA II; CA I