YM-201636

• Description:

  YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110α with an IC50 of 3.3 μM. YM-201636 inhibits retroviral replication.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Autophagy; Influenza Virus; PI3K; PIKfyve

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Autophagy; PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/ym-201636.html

• Purity:

  98.05

• Solubility:

  DMSO : ≥ 47 mg/mL

• Smiles:

  O=C (NC1=CC=CC (C2=NC (N3CCOCC3) =C4OC5=NC=CC=C5C4=N2) =C1) C6=CC=C (N=C6) N

• Molecular Formula:

  C25H21N7O3

• Molecular Weight:

  467.48

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Jefferies HB, et al. A selective PIKfyve inhibitor blocks PtdIns (3,5) P (2) production and disrupts endomembrane transport and retroviral budding. EMBO Rep, 2008, 9 (2), 164-170.|[2]Ikonomov OC, et al. YM-201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns (3,5) P2 synthesis, halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8;382 (3) :566-70.|[3]Sbrissa D, et al. Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns (3,5) P2 by means of the PIKfyve inhibitor YM-201636. Am J Physiol Cell Physiol. 2012 Aug 15;303 (4) :C436-46.|[4]Dukes JD, et al. The PIKfyve inhibitor YM-201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells. PLoS One. 2012;7 (3) :e28659.|[5]Ikonomov OC, et al. YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns (3,5) P2 synthesis, halts glucose entry by insulin in adipocytes. Biochem Biophys Res Commun. 2009 May 8;382 (3) :566-70.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PI3Kα

• CAS Number:

  371942-69-7