SB-334867

• Description :

  SB-334867 (SB 334867A) is an excellent, selective and blood-brain barrier permeable orexin-1 (OX1) receptor antagonist, shows selectivity over OX2 (pKb=7.4), 100-fold over 5-HT2B, 5-HT2C with pKi values of 5.4 and 5.3, respectively[1]. SB-334867 reduces ethanol consumption and inhibits the acquisition of morphine-induced sensitization to locomotor activity in vivo[2][3].

• CAS Number :

  [249889-64-3]

• Product Name Alternative :

  SB 334867A

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Orexin Receptor (OX Receptor)

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Neurological Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/sb-334867.html

• Purity :

  99.48

• Solubility :

  DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 20 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(NC1=CC(OC(C)=N2)=C2C=C1)NC3=CC=NC4=CC=CN=C43.Cl

• Molecular Formula :

  C17H14ClN5O2

• Molecular Weight :

  355.78

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Porter RA, et al. 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.Bioorg Med Chem Lett. 2001 Jul 23;11 (14) :1907-10.|[2] Łupina M, et al. SB-334867 (an Orexin-1 Receptor Antagonist) Effects on Morphine-Induced Sensitization in Mice-a View on Receptor Mechanisms.|[3]Anderson RI, et al. Orexin-1 and orexin-2 receptor antagonists reduce ethanol self-administration in high-drinking rodent models.Front Neurosci. 2014 Feb 25;8:33.|[4]Smart D, et al. SB-334867-A: the first selective orexin-1 receptor antagonist.Br J Pharmacol. 2001 Mar;132 (6) :1179-82.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT2 Receptor; OX1 Receptor