MT 63-78

• Description :

  MT 63-78 is a specific and potent direct AMPK activator with an EC50 of 25 μM. MT 63–78 also induces cell mitotic arrest and apoptosis. MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects[1].

• CAS Number :

  [1179347-65-9]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  AMPK; Apoptosis; mTOR

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Epigenetics; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mt-63-78.html

• Purity :

  98.00

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  N#CC1=CNC2=C1C=C(C3=CC=C(C4=C(O)C=CC=C4O)C=C3)C=C2

• Molecular Formula :

  C21H14N2O2

• Molecular Weight :

  326.35

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Zadra G, et al. A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis. EMBO Mol Med. 2014 Apr;6 (4) :519-38.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AMPK; mTORC1