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QX-314 (bromide)

CAT: 0804-HY-101350-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101350-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker[1].
CAS Number
24003-58-5
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/qx-314-bromide.html
Purity
96.62
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=C(C)C=CC=C1C)C[N+](CC)(CC)CC.[Br-]
Molecular Formula
C16H27BrN2O
Molecular Weight
343.30
References & Citations
[1]Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 2011 Jun;114 (6) :1425-34.|[2]Binshtok AM, et al. Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents. Anesthesiology. 2009 Jul;111 (1) :127-37.|[3]Talbot MJ, et al. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996 Sep;76 (3) :2120-4.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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