NK 314

• Description:

  NK 314 is an inhibitor for topoisomerase IIα, which generates the break of DNA double-strand. NK 314 arrests the cell cycle at G2 phase in human acute myeloid leukemia cells, inhibits the proliferation of CEM with IC90 of 55 nM[1].

• UNSPSC:

  12352005

• Target:

  Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nk-314.html

• Smiles:

  OC1=C(C=CC2=C1C(CCC3)=[N+]3C4=C5C=C6OCOC6=CC5=CC=C24)OC.[Cl-]

• Molecular Formula:

  C22H18ClNO4

• Molecular Weight:

  395.84

• References & Citations:

  [1]Guo L, et al., Inhibition of topoisomerase IIalpha and G2 cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials. Mol Cancer Ther. 2007 May;6 (5) :1501-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Topo II

• CAS Number:

  [208237-49-4]