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QX-314

CAT: 0804-HY-101350ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101350ASize:1 Each
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Description
QX-314 is a membrane-impermeable quaternary Lidocaine derivative with sensory-selective blocking effects. QX-314 inhibits acid-induced esophageal hypersensitivity. QX-314 enters jugular ganglion cells via TRPV1 channels, blocks NaV1.8 channels, and thereby inhibits esophageal sensory conduction. QX-314 can alleviate acid-induced esophageal inflammation. QX-314 can be used for the research on gastroesophageal reflux disease (GERD).
CAS Number
21306-56-9
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Sodium Channel; TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Inflammation/Immunology
Smiles
O=C(NC1=C(C)C=CC=C1C)C[N+](CC)(CC)CC
Molecular Formula
C16H27N2O
Molecular Weight
263.40
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Wu B, et al. QX-314 inhibits acid-induced esophageal hypersensitivity by regulating TRPV1/NaV1.8 receptor pathway. Int Immunopharmacol. 2025 Jun 5;157:114767.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
sc-3579QX-314
BQ166030-01QX 314
B7015-5.1QX 314 chloride
532485QX-314 Br
GTR19260795-01QX-314 bromide
TRC-Q950000-10GQX 314 Bromide
C12996-5mgQX-314 chloride

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