QX-314

• Description :

  QX-314 is a membrane-impermeable quaternary Lidocaine (HY-B0185) derivative with sensory-selective blocking effects. QX-314 inhibits acid-induced esophageal hypersensitivity. QX-314 enters jugular ganglion cells via TRPV1 channels, blocks NaV1.8 channels, and thereby inhibits esophageal sensory conduction. QX-314 can alleviate acid-induced esophageal inflammation. QX-314 can be used for the research on gastroesophageal reflux disease (GERD) [1].

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H335

• Target :

  Sodium Channel; TRP Channel

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research :

  Inflammation/Immunology

• Smiles :

  O=C(NC1=C(C)C=CC=C1C)C[N+](CC)(CC)CC

• Molecular Formula :

  C16H27N2O

• Molecular Weight :

  263.40

• Precautions :

  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Wu B, et al. QX-314 inhibits acid-induced esophageal hypersensitivity by regulating TRPV1/NaV1.8 receptor pathway. Int Immunopharmacol. 2025 Jun 5;157:114767.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [21306-56-9]