MB-314

• Description :

  MB-314 is a human IgG1 monoclonal antibody (mAb) targeting Lewis Y. MB-314 induces enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. MB-314 increases the release of IFN-γ, TNF-α, MCP-1, and IL-6. MB-314 can be used in cancer research[1].

• UNSPSC :

  12352203

• Target :

  IFNAR; TNF Receptor; Transmembrane Glycoprotein

• Related Pathways :

  Apoptosis; Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  [MB-314]

• References & Citations :

  [1]Kircheis R, et al. Correlation of ADCC activity with cytokine release induced by the stably expressed, glyco-engineered humanized Lewis Y-specific monoclonal antibody MB314. MAbs. 2012 Jul-Aug;4 (4) :532-41.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Inhibitory Antibodies

• Clinical Information :

  No Development Reported