MB-314

• Description:

  MB-314 is a human IgG1 monoclonal antibody (mAb) targeting Lewis Y. MB-314 induces enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) activity. MB-314 increases the release of IFN-γ, TNF-α, MCP-1, and IL-6. MB-314 can be used in cancer research[1].

• UNSPSC:

  12352203

• Target:

  IFNAR; TNF Receptor; Transmembrane Glycoprotein

• Related Pathways:

  Apoptosis; Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  [MB-314]

• References & Citations:

  [1]Kircheis R, et al. Correlation of ADCC activity with cytokine release induced by the stably expressed, glyco-engineered humanized Lewis Y-specific monoclonal antibody MB314. MAbs. 2012 Jul-Aug;4 (4) :532-41.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Inhibitory Antibodies

• Clinical Information:

  No Development Reported