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QX-222 (chloride)

CAT: 0804-HY-101362-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101362-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
QX-222 chloride, a trimethyl analogue of Lignocaine , is a potent Na+ channel blocker[1][2][3].
CAS Number
5369-00-6
UNSPSC
12352005
Hazard Statement
H302
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/qx-222-chloride.html
Concentration
10mM
Purity
96.31
Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=C(C)C=CC=C1C)C[N+](C)(C)C.[Cl-]
Molecular Formula
C13H21ClN2O
Molecular Weight
256.77
Precautions
H302
References & Citations
[1]A Sunami, et al. A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel. Proc Natl Acad Sci U S A. 2000 Feb 29;97 (5) :2326-31.|[2]Qingmin Chen, et al. Differential blockade of nerve injury-induced thermal and tactile hypersensitivity by systemically administered brain-penetrating and peripherally restricted local anesthetics. J Pain. 2004 Jun;5 (5) :281-9.|[3]J A Flatman, et al. Reversibility of Ia EPSP investigated with intracellularly iontophoresed QX-222. J Neurophysiol. 1982 Aug;48 (2) :419-30.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Lidocaine N-methyl hydrochloride
CAS Number5369-00-6
PubChem CID9795082
IUPAC Name[2-(2,6-dimethylanilino)-2-oxoethyl]-trimethylazanium chloride
Molecular FormulaC13H21ClN2O
Molecular Weight256.77
Topological Polar Surface Area29.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Heavy Atom Count17
Formal Charge0
Complexity235
SMILES
CC1=C(C(=CC=C1)C)NC(=O)C[N+](C)(C)C.[Cl-]
InChI
InChI=1S/C13H20N2O.ClH/c1-10-7-6-8-11(2)13(10)14-12(16)9-15(3,4)5;/h6-8H,9H2,1-5H3;1H
InChIKey
WFKXSWWTOZBDME-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Lidocaine N-methyl hydrochloride
CAS: 5369-00-6
CID: 9795082
Formula: C13H21ClN2O
MW: 256.77
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight256.77
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass256.1342410
Monoisotopic Mass256.1342410
Topological Polar Surface Area29.1 Ų
Heavy Atom Count17
Formal Charge0
Complexity235
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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