QX-314 (chloride)

• UNSPSC Description:

  QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker[1].

• Target Antigen:

  Sodium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/qx-314-chloride.html

• Purity:

  99.83

• Solubility:

  DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)|H2O : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1=C(C)C=CC=C1C)C[N+](CC)(CC)CC.[Cl-]

• Molecular Weight:

  298.85

• References & Citations:

  [1]Rivera-Acevedo RE, et al. The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro. Anesthesiology. 2011 Jun;114(6):1425-34.|[2]Talbot MJ, et al. Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1996 Sep;76(3):2120-4.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported

• CAS Number:

  5369-03-9