WQQ-345

• Description:

  WQQ-345 is a BCAT1 inhibitor with an IC50 value of 10.8 mM. WQQ-345 can lead to a decrease in α-KG levels, an upregulation of H3K27me3 expression, a reduction in the expression of glycolytic enzymes (PFKP and LDHA), and impaired glycolytic activity in 67R cells. WQQ-345 shows tumor-suppressing activity in a 67R subcutaneous xenograft model[1].

• UNSPSC:

  12352211

• Target:

  Aminotransferases (Transaminases) ; Histone Methyltransferase; Lactate Dehydrogenase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  O=C (O) C[C@]1 (CN) [C@] (C2) ([H]) CC[C@]2 ([H]) C1

• Molecular Formula:

  C10H17NO2

• Molecular Weight:

  183.25

• References & Citations:

  [1]Zhang T, et al. Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation. Signal Transduct Target Ther. 2024 Aug 15;9 (1) :216.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported