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PROTAC EZH2 Degrader-2

CAT: 0804-HY-157164-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-157164-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC EZH2 Degrader-2 is a PROTAC EZH2 inhibitor. PROTAC EZH2 Degrader-2 degrades EZH2 in SU-DHL-6 cells in a dose-dependent manner. PROTAC EZH2 Degrader-2 induces apoptosis and reduces mitochondrial membrane potential in SU-DHL-6 cells. PROTAC EZH2 Degrader-2 has anti-cancer and anti-proliferative activity. (Pink: EZH2 ligand , Blue: MDM2 Ligand (HY-147230), Black: Linker (HY-175707), EZH2 ligand-linker conjugate (HY-175706) ).
UNSPSC
12352005
Target
Apoptosis; Histone Methyltransferase; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-ezh2-degrader-2.html
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC(C)=C(CNC(C2=CC(C3=CC=C(CN4CCN(C(C5=CN(CCOCCOCCOCCNC(CN6CCN(C(N7C(C8=CC=C(OC)C=C8OC(C)C)=N[C@H](C9=CC=C(Cl)C=C9)[C@@H]7C%10=CC=C(Cl)C=C%10)=O)CC6=O)=O)N=N5)=O)CC4)C=C3)=CC(N(C%11CCOCC%11)CC)=C2C)=O)C(N1)=O
Molecular Formula
C77H93Cl2N13O12
Molecular Weight
1463.55
References & Citations
[1]Xie H et al. Design, synthesis and evaluation of EZH2-based PROTACs targeting PRC2 complex in lymphoma. Bioorg Chem. 2023 Nov;140:106762.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EZH2; MDM2

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