PROTAC EZH2 Degrader-3

PROTAC EZH2 Degrader-3

• UNSPSC Description: PROTAC EZH2 Degrader-3 (compound ZJ-20) is a EZH2 PROTAC degrader. PROTAC EZH2 Degrader-3 (5 μM, 24 h) not only potently inhibits the expression of EZH2 protein, but also had a strong inhibits effect on the expression levels of other subunits of PRC2 as well as H3k27me3 protein. PROTAC EZH2 Degrader-3 shows anti-proliferative activity and blocks the cell cycle in the G0-G1 phase and induces cell apoptosis((Blue: cereblon ligand Pomalidomide (HY-10984), Black: linker HY-W361751；Pink: EZH2 inhibitor Tazemetostat (HY-13803))[1].
• Target Antigen: Apoptosis; Histone Methyltransferase; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-ezh2-degrader-3.html
• Smiles: CCN(C1CCOCC1)C2=CC(C3=CC=C(CN4CCN(C(CC5CCC(CNC6=C(C(N(C7C(NC(CC7)=O)=O)C8=O)=O)C8=CC=C6)CC5)=O)CC4)C=C3)=CC(C(NCC9=C(C)C=C(C)NC9=O)=O)=C2C
• Molecular Weight: 981.19
• References & Citations: [1]Fu M, et al. Chemically induced degradation of PRC2 complex by EZH2-Targeted PROTACs via a Ubiquitin-Proteasome pathway. Bioorg Med Chem Lett. 2024;113:129968.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported