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Dapsone hydroxylamine

CAT: 0804-HY-137155-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137155-02Size:10 mg
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Description
Dapsone hydroxylamine (DDS-NOH) induces methemoglobinemia. Dapsone hydroxylamine inhibits catalase (CAT) activity and reactive oxygen species generation. Dapsone hydroxylamine also has anti-inflammatory activity[1].
CAS Number
32695-27-5
Product Name Alternative
DDS-NOH
UNSPSC
12352005
Hazard Statement
H302+H312
Target
Drug Metabolite; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dapsone-hydroxylamine.html
Purity
94.92
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(C=C1)N)(C2=CC=C(C=C2)NO)=O
Molecular Formula
C12H12N2O3S
Molecular Weight
264.30
Precautions
H302+H312
References & Citations
[1]Albuquerque RV, et al. In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells. PLoS One. 2015 Aug 18;10 (8) :e0134768.|[2]Wozel G, et al. Dapsone hydroxylamine inhibits the LTB4-induced chemotaxis of polymorphonuclear leukocytes into human skin: results of a pilot study. Inflamm Res. 1997 Oct;46 (10) :420-2.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Dapsone hydroxylamine

Dapsone hydroxylamine is a sulfonic acid derivative.

CAS Number32695-27-5
PubChem CID65387
IUPAC NameN-[4-(4-aminophenyl)sulfonylphenyl]hydroxylamine
Molecular FormulaC12H12N2O3S
Molecular Weight264.30
XLogP0.9
Topological Polar Surface Area101
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count18
Formal Charge0
Complexity350
SMILES
C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)NO
InChI
InChI=1S/C12H12N2O3S/c13-9-1-5-11(6-2-9)18(16,17)12-7-3-10(14-15)4-8-12/h1-8,14-15H,13H2
InChIKey
IYDSJDWESCGRKW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dapsone hydroxylamine
CAS: 32695-27-5
CID: 65387
Formula: C12H12N2O3S
MW: 264.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight264.30
XLogP30.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass264.05686342
Monoisotopic Mass264.05686342
Topological Polar Surface Area101 Ų
Heavy Atom Count18
Formal Charge0
Complexity350
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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