DM4

CAT: 0804-HY-12454-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12454-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody agent conjugate.
CAS Number
[796073-69-3]
Product Name Alternative
Ravtansine
UNSPSC
12352203
Hazard Statement
H315, H317, H318, H335, H341, H361, H370, H413
Target
ADC Payload; Microtubule/Tubulin
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/DM4.html
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@]1([C@H](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)OC([C@H](C)N(C)C(CCC(C)(S)C)=O)=O)[C@H]([C@@H]([C@](OC4=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N4)O)C)O1
Molecular Formula
C38H54ClN3O10S
Molecular Weight
780.37
Precautions
H315, H317, H318, H335, H341, H361, H370, H413
References & Citations
[1]Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported

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