DM4

• Description :

  DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody agent conjugate.

• CAS Number :

  [796073-69-3]

• Product Name Alternative :

  Ravtansine

• UNSPSC :

  12352203

• Hazard Statement :

  H315, H317, H318, H335, H341, H361, H370, H413

• Target :

  ADC Payload; Microtubule/Tubulin

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/DM4.html

• Purity :

  99.64

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C[C@]1([C@H](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)OC([C@H](C)N(C)C(CCC(C)(S)C)=O)=O)[C@H]([C@@H]([C@](OC4=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N4)O)C)O1

• Molecular Formula :

  C38H54ClN3O10S

• Molecular Weight :

  780.37

• Precautions :

  H315, H317, H318, H335, H341, H361, H370, H413

• References & Citations :

  [1]Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported