Products for Research Use Only
RegisterLogin

DM4

CAT: 0804-HY-12454-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-12454-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody agent conjugate.
CAS Number
796073-69-3
Product Name Alternative
Ravtansine
UNSPSC
12352203
Hazard Statement
H315, H317, H318, H335, H341, H361, H370, H413
Target
ADC Payload; Microtubule/Tubulin
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/DM4.html
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@]1([C@H](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)OC([C@H](C)N(C)C(CCC(C)(S)C)=O)=O)[C@H]([C@@H]([C@](OC4=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N4)O)C)O1
Molecular Formula
C38H54ClN3O10S
Molecular Weight
780.37
Precautions
H315, H317, H318, H335, H341, H361, H370, H413
References & Citations
[1]Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported

Alternative Products

CatalogName
CN-A038-500GMAgar, Micropropagation - Type I (Gracilaria)
M2302-20HPhaseShield™ Gel Tubes, Heavy (200x 2ml)
M2302-20LPhaseShield™ Gel Tubes, Light (200x 2ml)
BCS81BioCoupler® Glass Set (8 oz) x1
RHD55901Anti-PTGS1 Antibody (R1S27)
E-EL-H1579ELISA kit for Human PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9)
RHD55804Anti-TCEA1 Antibody (R1S24)
E-EL-M2699ELISA kit for Mouse ACTN1 (Actinin Alpha 1)
RHD55803Anti-TCEA1 Antibody (R1S23)
PKSH030904Recombinant Human Purine nucleoside phosphorylase/PNP Protein (His Tag)

Popular Products