IHMT-MST1-39

• UNSPSC Description:

  IHMT-MST1-39 is an orally active inhibitor for MST kinase, with IC50 of 42 nM and 109 nM, for MST1 and MST2. IHMT-MST1-39 activates the AMPK signaling pathway in liver cells, reduces apoptosis of pancreatic β-cells. IHMT-MST1-39 ameliorates diabetes in Streptozotocin (HY-13753)-induced type 1 diabetes (T1D) mouse models[1].

• Target Antigen:

  AMPK; Apoptosis; Hippo (MST)

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Epigenetics;PI3K/Akt/mTOR;Stem Cell/Wnt

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/ihmt-mst1-39.html

• Smiles:

  O=C1N(C)C2=CN=C(NC3=CC=C(S(=O)(N)=O)C=C3)N=C2N(C1C4=C(F)C=CC=C4F)C

• Molecular Weight:

  460.46

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2414484-01-6