IHMT-15130

• Description:

  IHMT-15130 is a highly potent irreversible BMX kinase inhibitor (IC50=1.47 nM) . IHMT-15130 inhibits the secretion of inflammatory cytokines, blocks inflammatory signaling pathways, and alleviates Angiotensin II-induced myocardial hypertrophy in mice. IHMT-15130 is promising for research of myocardial hypertrophy[1].

• UNSPSC:

  12352005

• Target:

  BMX Kinase

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Smiles:

  O=C(CC1=CC(NC(C=C)=O)=CC=C1)NC2=CNN=C2C3=NC4=CC(C(F)(F)F)=CC=C4N3

• Molecular Formula:

  C22H17F3N6O2

• Molecular Weight:

  454.40

• References & Citations:

  [1]Qi S, et al. Discovery of IHMT-15130 as a Highly Potent Irreversible BMX Inhibitor for the Treatment of Myocardial Hypertrophy and Remodeling. ACS Chem Biol. 2025 May 19.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported