IHMT-RAF-128

• UNSPSC Description:

  IHMT-RAF-128, a highly potent pan-RAF inhibitor. IHMT-RAF-128 shows potent antitumor efficacy in xenograft mouse tumor models without causing any apparent toxicities[1][2].

• Target Antigen:

  Raf

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ihmt-raf-128.html

• Smiles:

  FC(F)(F)C1=CC(C(NC2=CC(N3N=CC(C4=CC(N5CCOCC5)=CN=C4)=C3)=C(C)C=C2)=O)=CC=C1

• Molecular Weight:

  507.51

• References & Citations:

  [1]Olaoba OT, et al. Driver Mutations in Pancreatic Cancer and Opportunities for Targeted Therapy. Cancers (Basel). 2024 May 9;16(10):1808.|[2]Wang A, et al. Discovery of a highly potent pan-RAF inhibitor IHMT-RAF-128 for cancer treatment. Eur J Pharmacol. 2023 Aug 5;952:175752.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2479289-15-9