IHMT-EZH2-426

• Target :

  Histone Methyltransferase

• Related Pathways :

  Chromatin/Epigenetic

• Bioactivity :

  IHMT-EZH2-426 (compound 38) is a potent covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5 nM for EZH2-Y641F/Y641N/Y641S mutants. The compound effectively inhibits proliferation in B-cell lymphoma and triple-negative breast cancer (TNBC) cell lines due to its capacity to diminish H3K27me3 and EZH2 levels [1].

• Molecular Formula :

  C31H35FN4O4S

• Molecular Weight :

  578.7

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C