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IHMT-EZH2-426

CAT: 0931-T79780-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T79780-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Bioactivity
IHMT-EZH2-426 (compound 38) is a potent covalent degrader of EZH2, demonstrating IC50 values of 1.3 nM for EZH2 wild-type, 1.2 nM for EZH2-A687V, and 1.7-3.5 nM for EZH2-Y641F/Y641N/Y641S mutants. The compound effectively inhibits proliferation in B-cell lymphoma and triple-negative breast cancer (TNBC) cell lines due to its capacity to diminish H3K27me3 and EZH2 levels [1].
Molecular Formula
C31H35FN4O4S
Molecular Weight
578.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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