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PROTAC SMARCA2/4-degrader-8

CAT: 0931-T88872-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T88872-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2568507-14-0
Bioactivity
PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader targeting the catalytic subunit SMARCA of the SWI/SNF complex. It degrades SMARCA2 in A549 and MV411 cells with a DC50 of <100 nM and SMARCA4 in MV411 cells, also exhibiting a DC50 of <100 nM.
Smiles
NC1=C(N2CC3N(C(C2)CC3)C=4N=CC(=CN4)C5CCC(CC(N[C@H](C(=O)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6)C(C)(C)C)=O)CC5)C=C(N=N1)C9=C(O)C=CC=C9
Molecular Formula
C50H61N11O5S
Molecular Weight
928.16
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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