R-348 (choline)

• Description:

  R-348 (R-932348) choline is a potent and orally active JAK3 and Syk inhibitor. R-348 reduces IFN-γ, IL-6, and IL-10 expression. R-348 effectively diminishes acute cardiac allograft rejection[1].

• Product Name Alternative:

  R-932348 (choline)

• UNSPSC:

  12352005

• Target:

  Interleukin Related; JAK; Syk

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/r-348-choline.html

• Smiles:

  C[N+] (CCO) (C) C.CCC ([N-]S (=O) (C1=CC (NC2=NC=C (C (NC3=CC=C (C=C3) OCC#C) =N2) F) =CC=C1C) =O) =O

• Molecular Formula:

  C28H35FN6O5S

• Molecular Weight:

  586.68

• References & Citations:

  [1]Deuse T, et al. Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection. Transplantation. 2008 Mar 27;85 (6) :885-92.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  IL-10; IL-6; JAK3

• CAS Number:

  1620142-65-5