R-348 (choline)

CAT: 0804-HY-123625Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-123625Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
R-348 (R-932348) choline is a potent and orally active JAK3 and Syk inhibitor. R-348 reduces IFN-γ, IL-6, and IL-10 expression. R-348 effectively diminishes acute cardiac allograft rejection[1].
CAS Number
[1620142-65-5]
Product Name Alternative
R-932348 (choline)
UNSPSC
12352005
Target
Interleukin Related; JAK; Syk
Type
Reference compound
Related Pathways
Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/r-348-choline.html
Smiles
C[N+](CCO)(C)C.CCC([N-]S(=O)(C1=CC(NC2=NC=C(C(NC3=CC=C(C=C3)OCC#C)=N2)F)=CC=C1C)=O)=O
Molecular Formula
C28H35FN6O5S
Molecular Weight
586.68
References & Citations
[1]Deuse T, et al. Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection. Transplantation. 2008 Mar 27;85 (6) :885-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
IL-10; IL-6; JAK3

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