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Salicylate (choline)

CAT: 0804-HY-W338346Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W338346Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Salicylate choline is an orally active derivative of Aspirin (acetylsalicylic acid). Salicylate choline significantly reduces IL-1β, IL-6, TNF-α and IL-10 levels in cells. Salicylate choline enhances the anti-tumor activity of the CRM1 inhibitor Selinexor (KPT-330) (HY-17536) through inducing S-phase cell cycle arrest and impairing DNA damage repair. Salicylate choline combined with Selinexor demonstrates excellent anti-tumor efficacy in mice xenograft model harboring JeKo-1 cells. Salicylate choline can be used for the study of rheumatic diseases, inflammation and cancer[1][2][3][4].
CAS Number
2016-36-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Drug Derivative; Interleukin Related; Polo-like Kinase (PLK) ; TNF Receptor
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Others
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(O)C1=CC=CC=C1[O-].C[N+](C)(CCO)C
Molecular Formula
C12H19NO4
Molecular Weight
241.28
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Wróblewska KB, et al. Choline Salicylate Analysis: Chemical Stability and Degradation Product Identification. Molecules. 2019 Dec 22;25 (1) :51. |[2]SCULLY FJ. Choline salicylate: an effective, well-tolerated drug for treatment of rheumatic diseases. South Med J. 1960 Jan;53:12-6. |[3]Tiras M, et al. In vitro assessment of cytokine modulation by choline salicylate, hyaluronic acid, lidocaine-based six different teething gels in human gingival fibroblast cells. Odontology. 2025 May 13. |[4]Abeykoon JP, et al. Salicylates enhance CRM1 inhibitor antitumor activity by induction of S-phase arrest and impairment of DNA-damage repair. Blood. 2021 Jan 28;137 (4) :513-523.
Shipping Conditions
Room temperature
Scientific Category
Reference compound2
Clinical Information
No Development Reported

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